Projects

[accepted] S.T. Tandar, L.B. Zwep, G. Forn Cuni, A. Liakopoulos, A. F. Schoffelen, S. Beisken, J.J. Meulman & J.G.C. Van Hasselt: Inference of collateral sensitivity effects in large scale antimicrobial resistance surveillance data

[accepted] H. van de Beek, P.A.J. Välitalo, J.G.C. van Hasselt, L.B. Zwep: Aggregate data modelling: a fast implementation for fitting pharmacometrics models to summary-level data in R. Journal of Pharmacokinetics and Pharmacodynamics

Publications

M. Kok, L.B. Zwep, R.S. Jansen, T. Hankemeier, J.G.C. van Hasselt (2025): Nutrients drive the antibiotic-specific evolution of resistance in Pseudomonas aeruginosa. Research in Microbiology

A.C. Alarcon Rios, L.B. Zwep, B. Vriesendorp, C.A.J. Knibbe, O. Ciofu, A. Liakopoulos, L.B.S. Aulin, D.E. Rozen, J.G.C. van Hasselt (2025): Colistin resistance dynamics in Pseudomonas aeruginosa under biofilm and planktonic growth. Antimicrobial Agents and Chemotherapy

Y. Guo, T. Guo, C.A. J. Knibbe, L.B. Zwep & J.G.C. van Hasselt (2024): Generation of realistic virtual adult populations using a model-based copula approach. Journal of Pharmacokinetics and Pharmacodynamics

I. den Hartog*, L.B. Zwep*, J.J. Meulman, T. Hankemeier, E.M.W. van de Garde & J.G.C. van Hasselt (2024): Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia. Metabolomics

I. den Hartog, N. Karu, L.B. Zwep, G.P. Voorn, E.M.W. van de Garde, T. Hankemeier & J.G.C. van Hasselt (2023): Differential metabolic host response to pathogens associated with community-acquired pneumonia. Metabolism Open

L.B. Zwep, T. Guo, T. Nagler, C.A.J. Knibbe, J.J. Meulman & J.G.C. Van Hasselt (2023): Virtual patient simulation using copula modeling. Clinical Pharmacology & Therapeutics

L.B. Zwep (thesis, 2023): Statistical learning for complex data to enable precision medicine strategies.

L.B. Zwep, Y. Haakman, K.L.W. Duisters, J.J. Meulman, A. Liakopoulos & J.G.C. van Hasselt (2021): Identification of collateral effects of antibiotic resistance in population surveillance data. JAC-Antimicrobial Resistance

I. den Hartog, L.B. Zwep, S.M.T. Vestjens, A.C. Harms, G.P. Voorn, D.W. de Lange, W.J.W. Bos, T. Hankemeier, E.M.W. van de Garde & J.G.C. van Hasselt (2021): Metabolomic profiling of microbial disease etiology in community-acquired pneumonia. PLoS ONE

L.B. Zwep, K.L.W. Duisters, M. Jansen, T. Guo, J.J. Meulman, P.J. Upadhyay & J.G.C. van Hasselt (2021): Identification of high-dimensional omics-derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling. CPT: Pharmacometrics & Systems Pharmacology

M. Malosetti, L.B. Zwep, K. Forrest, F.A. van Eeuwijk & M. Dieters (2020): Lessons from a GWAS study of a wheat pre-breeding program: pyramiding resistance alleles to Fusarium crown rot. Theoretical and Applied Genetics

T. Guo, R.M. van Hest, L.B. Zwep, L.F. Roggeveen, L.M. Fleuren, R.J Bosman, P.H.J. van der Voort, A.R.J. Girbes, R.A.A. Mathot, P.W.G. Elbers & J.G.C. van Hasselt (2020): Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients. Pharmaceutical Research

S.C. Goulooze, L.B. Zwep, J.E. Vogt, E.H.J. Krekels, T. Hankemeier, J.N. van den Anker & C.A.J. Knibbe (2020): Beyond the randomized clinical trial: innovative data science to close the pediatric evidence gap. Clinical Pharmacology and Therapeutics.

Last updated: 4-12-2025